therefore; consequently; accordingly
A logical conjunction used at the beginning of a sentence or clause to state a natural result or conclusion based on the preceding context. Common in both spoken and written Japanese.
See also: に従って
明日は祝日だ。したがって、学校は休みだ。
Tomorrow is a national holiday. Therefore, school is closed.
この製品は需要が高い。したがって、価格が上がるだろう。
This product is in high demand. Accordingly, the price will likely rise.
したがって is the standard formal conjunction for 'therefore', while 以て can serve the same role in more literary or old-fashioned writing.
従って is a formal, written 'therefore' used in logical arguments, while そこで is used more broadly in narrative to mark a resulting action.