Refers to a dark spot on the skin, either a congenital mole or a beauty mark. The medical term 'lentigo' is a more technical synonym.
She has a small mole on her cheek.
そのほくろは昔からある。
That mole has been there for a long time.
She has a mole on her cheek.
A new mole has recently appeared on my shoulder.
I had a mole removed with a laser.