Usage patterns
〈事〉を第一に考えるto consider X the top priority
You should consider your health as the top priority.
第一に、〈事〉first of all, ...
First of all, the budget isn't enough.
〈事〉が第一だX is the most important thing
Family comes before work; family is the most important thing.
Expressions
保身第一self-preservation first; looking out for oneself above all まず第一にfirst of all; to begin with; in the first place