Usage patterns
〈物〉に染みができるa stain forms on something
A soy sauce stain formed on the shirt.
顔に染みが出るskin spots appear on one's face
As you get older, spots tend to appear on your face more easily.
染みが付くa stain gets on something
A wine stain got on the tablecloth.
染みを消すto erase/fade a skin spot
I want to fade the skin spots with a beauty cream.
染みを取るto remove a stain
You can remove the stain with this detergent.
Expressions
知らぬ神より馴染みの鬼better the devil you know than the devil you don't; a familiar ogre is better than an unknown god