When you're in trouble, ask your friends for help.
彼は私の一番の助けになってくれた。
He was my greatest support.
He asked his neighbor for help.
This task needs everyone's help.
With a friend's help, I found a new job.
When the fight started, he stepped in to help.
助け is a broader, more emotionally weighted word for help or aid (even in emergencies), while お手伝い is the everyday polite word for lending a hand with tasks.
助け is general help or aid given in a moment of need, whereas 支え suggests ongoing, steady support that sustains someone.
helping others; kind deed; kindness
help each other; cooperate