Usage patterns
休みを取るto take a day off / take time off
I'm planning to take some time off next week and go on a trip.
〈場所〉は休みだused to say a shop, office, or school is closed
This shop is closed today.
休みになるto go on break / become a holiday period
Starting next week, school will be on summer vacation.
休みを利用するto make use of a break/holiday (to do something)
I used my time off to go back to my parents' house.
Expressions
休み明けjust after a holiday break; the first day back after a holiday